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Cat Scratch Disease as a Mimicker of Malignancy

Abstract Cat scratch disease (CSD) infrequently mimics malignancy. We reviewed 11 such cases at MD Anderson Cancer Center and an additional 36 reported from the literature. Breast cancer, sarcoma, and lymphoma were the most commonly suspected malignancies. Most patients were young, female, had prior cat exposure, and had no systemic symptoms. Regional lymphadenopathy was the…

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Detection of Anaplasma phagocytophilum, Babesia odocoilei, Babesia sp., Borrelia burgdorferi Sensu Lato, and Hepatozoon canis in Ixodes scapularis Ticks Collected in Eastern Canada

Abstract Tick-borne pathogens cause infectious diseases that inflict much societal and financial hardship worldwide. Blacklegged ticks, Ixodes scapularis, are primary vectors of several epizootic and zoonotic pathogens. The aim sets forth the pathogens and their prevalence. In Ontario and Quebec, 113 I. scapularis ticks were collected from songbirds, mammals, including humans, and by flagging. PCR and DNA sequencing…

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Open AccessArticle Tick-Borne Surveillance Patterns in Perceived Non-Endemic Geographic Areas: Human Tick Encounters and Disease Outcomes

Quote from Discussion section of paper: “Given that LD is often labeled a “contested illness,” TTS respondents who may be perceived as “faking it” could easily report any random county if their tick bites were indeed a false entry in the TTS survey. In other words, it would be highly unlikely that the totality of…

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A novel Borrelia species, intermediate between Lyme disease and relapsing fever groups, in neotropical passerine-associated ticks

Abstract Lyme disease (LD) and relapsing fevers (RF) are vector-borne diseases caused by bacteria of the Borrelia genus. Here, we report on the widespread infection by a non-described Borrelia species in passerine-associated ticks in tropical rainforests of French Guiana, South America. This novel Borrelia species is common in two tick species, Amblyomma longirostre and A….

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Antibiotic Susceptibility of Bartonella Grown in Different Culture Conditions

Abstract Bartonellosis is caused by a Gram-negative intracellular bacterium with a zoonotic transmission. The disease, caused by any of several genospecies of Bartonella can range from a benign, self-limited condition to a highly morbid and life-threatening illness. The current standard of care antibiotics are generally effective in acute infection; these include azithromycin or erythromycin, doxycycline, gentamicin, rifampin,…

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Brain fog, mysterious infections, not believed – Atlantic Canadians still struggling to get faster Lyme disease diagnosis

June 8th 2021 “The (symptoms) affected every system in my body, pretty much,” said Lugar, who was experiencing vision, hearing, and digestive issues, as well as extreme fatigue and light and sound sensitivity. “At my worst, I was in bed, in a darkened room. At my best, I could function at about 60 per cent.”…

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Interagency Cooperation Drives Discovery of Lyme Disease Spirochete in Exotic Tick

“Since inception, the primary goal of the tick program has been to collect and test blacklegged ticks because of the public health risk they pose. However, over time and through targeted collections throughout the Commonwealth, established populations of additional tick species have been discovered. One of those species is the newly invasive Asian longhorned tick…


BC, Canada: Penticton dog paralyzed after being bitten by a tick

“It’s a good time to not just check yourself for ticks, but your furry companions too. A Penticton couple knew their dog hadn’t been feeling well over the past few days, but was shocked to find their dog had been paralyzed from a tick on its body. Brenda Blatz and her husband have a 16-year-old…

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Detection of Babesia odocoilei in Humans with Babesiosis Symptoms

Abstract Human babesiosis is a life-threatening infectious disease that causes societal and economic impact worldwide. Several species of Babesia cause babesiosis in terrestrial vertebrates, including humans. A one-day clinic was held in Ontario, Canada, to see if a red blood cell parasite, which is present in blacklegged ticks, Ixodes scapularis, is present in humans. Based on PCR testing…

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Detection of Babesia odocoilei in Ixodes scapularis Ticks Collected in Southern Ontario, Canada

Abstract Tick-borne zoonotic diseases have an economic and societal impact on the well-being of people worldwide. In the present study, a high frequency of Babesia odocoilei, a red blood cell parasite, was observed in the Huronia area of Ontario, Canada. Notably, 71% (15/21) blacklegged ticks, Ixodes scapularis, collected from canine and feline hosts were infected with B. odocoilei….

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Botanical Medicines Cryptolepis sanguinolenta, Artemisia annua, Scutellaria baicalensis, Polygonum cuspidatum, and Alchornea cordifolia Demonstrate Inhibitory Activity Against Babesia duncani

Front. Cell. Infect. Microbiol., 08 March 2021 | https://doi.org/10.3389/fcimb.2021.624745 “Human babesiosis is a CDC reportable disease in the United States and is recognized as an emerging health risk in multiple parts of the world. The current treatment for human babesiosis is suboptimal due to treatment failures and unwanted side effects. Although Babesia duncani was first described almost…

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Bartonella henselae Neuroretinitis: A Rare Coinfection in POEMS Syndrome

Abstract Bartonella henselae is a recognized cause of neuroretinitis in cat scratch disease. Meanwhile, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome with Castleman disease (evidence of lymph node hyperplasia), is a chronic debilitating condition that predisposes to various superimposed infections. B. henselae neuroretinitis implicated in POEMS syndrome has not been reported previously. A…

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Canada’s CTV investigative reporting show W5 explores Lyme disease: Bitten

Nov. 21, 2020 W5 TV show delves into Lyme disease and the lack of proper diagnostics and treatment in Canada. Patients stories are told and important issues are discussed that can affect most Canadians either by themselves, family or friends in the coming years. Watch Bitten

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Evaluation of pathogen specific urinary peptides in tick-borne illnesses

Abstract Mass spectrometry enhanced by nanotechnology can achieve previously unattainable sensitivity for characterizing urinary pathogen-derived peptides. We utilized mass spectrometry enhanced by affinity hydrogel particles (analytical sensitivity = 2.5 pg/mL) to study tick pathogen-specific proteins shed in the urine of patients with (1) erythema migrans rash and acute symptoms, (2) post treatment Lyme disease syndrome (PTLDS), and (3)…

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Canada: Microbiome Composition and Borrelia Detection in Ixodes scapularis Ticks at the Northwestern Edge of Their Range

Abstract Lyme disease-causing Borrelia burgdorferi has been reported in 10–19% of Ixodes ticks from Alberta, Canada, where the tick vector Ixodes scapularis is at the northwestern edge of its range. However, the presence of Borrelia has not been verified independently, and the bacterial microbiome of these ticks has not been described. We performed 16S rRNA bacterial surveys on female I. scapularis from Alberta that were…