Research
CanLyme is dedicated to promoting advancements in Lyme disease research. More research is needed to accurately diagnose and treat Lyme disease and other tick-borne illnesses, and CanLyme supports this. CanLyme’s Venture Grants policy for academic researchers can be found here.
Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination
Abstract Lyme disease is the most common vector-borne disease in North America and Europe. The clinical manifestations of Lyme disease vary based on the genospecies of the infecting Borrelia burgdorferi spirochete, but…
Case study demonstrates need for increased Lyme literacy among health practitioners
A new patient focused Lyme disease study funded by CanLyme explores the experiences of a Canadian adolescent with symptom-persistent Lyme disease. Lyme disease is the most prevalent vector-borne illness in…
Alternative Lyme disease treatments
Alternative Lyme disease treatments are popular either used alone or in conjunction with antibiotics.1For information about the MyLymeData Registry, see the MyLymeData Viz Blog: “MyLymeData is one of the largest…
Children are more than twice as likely to lose their detectable antibodies to Lyme disease bacteria
Background Lyme borreliosis (LB), caused by Borrelia burgdorferi (Bb), is the most common tick-borne infection in Germany. Antibodies against Bb are prevalent in the general population but information on temporal changes of prevalence and…
Toward a common research agenda in infection
In June, 2023 the U.S. National Academies of Science, Engineering and Medicine [NASEM] held a two day forum that many of us have long been hoping for.2Learn more about the…
Call for better combination treatments and diagnostics for Lyme
A number of chronic illnesses, from persistent Lyme disease to long COVID, have been associated with prior infectious disease. However, the pathogenesis mechanisms and link between infection and long-lasting symptoms…
Female ticks (Ixodes scapularis) infected with Borrelia burgdorferi have increased overwintering survival, with implications for tick population growth
Abstract The tick, Ixodes scapularis, vectors pathogens such as Borrelia burgdorferi, the bacterium that causes Lyme disease. Over the last few decades I. scapularis has expanded its range, introducing a novel health threat into…
Complete Remission in Paralytic Late Tick-Borne Neurological Disease Comprising Mixed Involvement of Borrelia, Babesia, Anaplasma, and Bartonella: Use of Long-Term Treatments with Antibiotics and Antiparasitics in a Series of 10 Cases
Abstract This study aimed to demonstrate that severe neurological motor deficits in the context of late tick-borne disease with mixed microorganism involvement are eligible for long-term combined antibiotic/antiparasitic treatments. The…
Primary Detection of the Establishment of Blacklegged Ticks, Ixodes scapularis, in British Columbia, Canada
Abstract Ticks transport and transmit microbial pathogens that inflict malevolent diseases on domestic and wildlife animals, and humans. We reveal the first-time record of the blacklegged tick, Ixodes scapularis, in…
Complete Remission in Paralytic Late Tick-Borne Neurological Disease Comprising Mixed Involvement of Borrelia, Babesia, Anaplasma, and Bartonella: Use of Long-Term Treatments with Antibiotics and Antiparasitics in a Series of 10 Cases
Abstract This study aimed to demonstrate that severe neurological motor deficits in the context of late tick-borne disease with mixed microorganism involvement are eligible for long-term combined antibiotic/antiparasitic treatments. The…
Identification of an unusual cluster of human granulocytic anaplasmosis in the Estrie region, Québec, Canada in 2021
Abstract Background: Human granulocytic anaplasmosis (HGA) is a potentially severe tick-borne infection caused by the bacterium Anaplasma phagocytophilum (A. phagocytophilum) of the genus Rickettsia. Here, we describe the epidemiological and…
Explore the Geneticks interactive tick testing map
Learn more about where ticks are in Canada by exploring this interactive tick testing & statistics map. Geneticks created the map from ticks sent in for testing from across the…