Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease

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“Persister research needs to account for morphological variability of Lyme

The patient population studied was already a group that had shown persistence of disease. These would be “treatment failures” and more difficult cases. Even in this difficult population every group who received 2 weeks of IV ceftriaxone made an average 5 point improvement, and this 5 point improvement from their baseline essentially continued for a year after the conclusion of treatment, giving a new improved baseline. Ceftriaxone acts on the cell wall, whereas doxycycline and clarithromycin have intracellular activity…..”

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