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Detecting Borrelia Spirochetes: A Case Study With Validation Among Autopsy Specimens

The complex etiology of neurodegenerative disease has prompted studies on multiple mechanisms including genetic predisposition, brain biochemistry, immunological responses, and microbial insult. In particular, Lyme disease is often associated with neurocognitive impairment with variable manifestations between patients. We sought to develop methods to reliably detect Borrelia burgdorferi, the spirochete bacteria responsible for Lyme disease, in autopsy…

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Chronic persistent late Lyme disease not a new phenomenon

Chronic Lyme borreliosis in the laboratory mouse. Am J Pathol. 1993 Sep; 143(3): 959–971 Abstract C3H/HeJ mice were inoculated intraperitoneally with 10(7) uncloned Borrelia burgdorferi at 4 weeks of age and examined on days 30, 90, 180, and 360. Spirochetes were isolated from multiple tissues at all intervals. Joint and heart disease were present in…

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The Borrelia hermsii factor H binding protein FhbA is not required for infectivity in mice or for resistance to human complement in vitro.

[CanLyme note: Currently, testing and symptomotology knowledge are not nearly accurate enough to distinguish between a human B. hermsii infection and a B.burgdorferi infection yet many people are told they do not have a treatable borreliosis simply because they do not have a positive Borrelia burgdorferi strain B31 when we have many other borrelia, and some we…

Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library

Jie Feng1, Ting Wang1, Wanliang Shi1, Shuo Zhang1, David Sullivan1, Paul G Auwaerter2 and Ying Zhang1 1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA 2Fisher Center for Environmental Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA Correspondence: Y Zhang, E-mail: yzhang@jhsph.edu…

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HHS Working Group on Lyme and Other Tickborne Diseases Webinar – May 22, 2014 Archive

  The HHS Working Group on Lyme and Other Tickborne Diseases invites you to listen to the archived webinar with experts scientists that took place on May 22, 2014. Listen to Dr. Stephen Barthold, Dr. Linda Bockenstedt, Dr. Monica Embers, Dr. Adriana Marques, and Dr. Linden Hu give their presentations and answer questions from individuals who were…

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Persister Formation in Borrelia burgdorferi

B. Sharma, A. Brown, K. Lewis; Northeastern Univ., Boston, MA Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne infection in North America and Europe. In 10-20% of cases, patients develop chronic Lyme disease after completing antibiotic treatment. The cause of these chronic symptoms is, however, poorly understood. We have previously…

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Huffington Post: The Global Search for Education: The 300,000 – Ticks

C. M. Rubin Blogger and author, ‘The Real Alice in Wonderland Posted: November 9th, 2013  The “We are the 300,000” campaign is a new grassroots campaign by the Lyme community to raise awareness for more effective treatments for all people suffering from Lyme disease. According to the CDC, there are 300,000 individuals who are affected…

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Persistence of the Lyme Disease Spirochete

Many thanks to researcher John D. Scott of the Lyme Disease Association of Ontario for providing this valuable and comprehensive list. The following references for persistence of Lyme disease (Lyme borreliosis) are listed alphabetically and then chronologically for the author of more than one publication:  Aalto A, Sjowall J, Davidsson L, Forsberg P, Smedby O….

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Pathogenic analysis of Borrelia garinii strain SZ isolated from northeastern China

BACKGROUND: Various genospecies of Borrelia burgdorferi sensu lato (s.l.) have been identified from patients and animals worldwide. Genospecies-related dissemination of disease has been reported. The present study aimed to elucidate the pathogenicity of infections caused by B. garinii SZ isolated in China. B. burgdorferi B31 and B. afzelii BO23 were used for comparison. METHODS: Spirochete…