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Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity

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Tao Lin1*, Lihui Gao1, Chuhua Zhang1, Evelyn Odeh1, Mary B. Jacobs3, Loïc Coutte1¤, George Chaconas4, Mario T. Philipp3, Steven J. Norris1,2 ABSTRACT The identification of genes important in the pathogenesis of Lyme disease Borrelia has been hampered by exceedingly low transformation rates in low-passage, infectious organisms. Using the infectious, moderately transformable B. burgdorferi derivative 5A18NP1…

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Lyme disease test kits and limitations

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Health Canada : “Lyme disease test kits are class II (IV being the highest risk class) in vitro diagnostic devices. The devices are intended for the detection of antibodies to Borrelia burgdorferi in human serum, plasma or cerebrospinal fluid.1 They are used to provide serologic evidence of B. Burgdorferi  exposure.1 Infection can result in dermatologic,…

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Goldhawk Fights Back am740 Zoomers radio – October 17th, 2012- Lyme

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Lyme disease was the very hot topic on today’s popular Dale Goldhawk radio show “Goldhawk Fights Back” on Am 740 Zoomer radio in Toronto, Ontario, Canada.  (apologies from Jim Wilson who said a Lyme society was first formed in 1889 when in fact it is quite obvious he should of said 1989). Listen to the podcast…

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1993, Calgary Herald newspaper … Lyme disease victims tell their story

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Lyme disease is not new to Canada, it has been around for centuries.  The finding that the Iceman, a 5000 yr old well preserved mummy found in the ice of the Alps, had Lyme disease tells us the Lyme bacteria has been around for millenia.  Just don’t tell that to your typical Infectious Disease doctors who…

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Diastolic Heart Murmur, Nocturnal Back Pain, and Lumbar Rigidity in a 7-Year Girl: An Unusual Manifestation of Lyme Disease in Childhood

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Case Reports in Pediatrics Volume 2012 (2012), Article ID 976961, 3 pagesdoi:10.1155/2012/976961 Case Report Diastolic Heart Murmur, Nocturnal Back Pain, and Lumbar Rigidity in a 7-Year Girl: An Unusual Manifestation of Lyme Disease in Childhood Genn Kameda,1 Silvia Vieker,1 Johannes Hartmann,2 Tim Niehues,3 and Alfred Längler4 1 Department for Child and Adolescent Health, Gemeinschaftskrankenhaus, Gerhard-Kienle…

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Evolving Perspectives on Lyme Borreliosis in Canada

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J.L.H. Sperling1,2, M.J. Middelveen2, D. Klein3, and F.A.H. Sperling*,1 1Department of Biological Sciences, University of Alberta, Edmonton, Canada 2Canadian Lyme Disease Foundation, West Kelowna, British Columbia, Canada 3Department of Family Medicine, University of Alberta, Edmonton, Canada Abstract: With cases now documented in every province, Lyme borreliosis (LB) is emerging as a serious public health risk…

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The Lymphocyte Transformation Test for Borrelia Detects Active Lyme Borreliosis and Verifies Effective Antibiotic Treatment

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Volker von Baehr, Cornelia Doebis, Hans-Dieter Volk, Rüdiger von Baehr Published Date: (05 October, 2012) Borrelia-specific antibodies are not detectable until several weeks after infection and even if they are present, they are no proof of an active infection. Since the sensitivity of culture and PCR for the diagnosis or exclusion of borreliosis is too…

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Chronic or Late Lyme Neuroborreliosis: Present and Future

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Judith Miklossy*, Samuel Donta, Kurt Mueller, Oliver Nolte and George Perry Alzheimer Research Center, Prevention Alzheimer International Foundation, 1921 Martigny-Croix, CP 16, Switzerland This special issue gives a framework of an international effort, to critically and constructively overview the clinical and pathological aspects of Lyme neuroborreliosis and show directions for future practice and research. The…

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A Reappraisal of the U.S. Clinical Trials of Post-Treatment Lyme Disease Syndrome

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Brian A. Fallon, Eva Petkova, John G. Keilp and Carolyn B. Britton Published Date: (05 October, 2012) Four federally funded randomized placebo-controlled treatment trials of post-treatment Lyme syndrome in the United States have been conducted. Most international treatment guidelines summarize these trials as having shown no acute or sustained benefit to repeated antibiotic therapy. The…

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The Psychoimmunology of Lyme/Tick-Borne Diseases and its Association with Neuropsychiatric Symptoms

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Robert C. Bransfield* Abstract: Disease progression of neuropsychiatric symptoms in Lyme/tick-borne diseases can be better understood by greater attention to psychoimmunology. Although there are multiple contributors that provoke and weaken the immune system, infections and persistent infections are significant causes of pathological immune reactions. Immune mediated ef-fects are a significant contributor to the pathophysiological processes…

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PETITION TO THE HOUSE OF COMMONS IN PARLIAMENT ASSEMBLED

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Elizabeth May, Member of Parliament, has started a petition and is asking that everyone participate in getting as many signatures as possible…. We, the undersigned, citizens of Canada draw the attention of the House to the following: THAT, Whereas Lyme disease is an illness caused by the bacterium Borrelia burgdorferi that is spread to humans…

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Vancouver, BC: 8th Annual LDF International Scientific Conference on Lyme Borreliosis and other Spirochetal and Tick-borne Diseases: with an emphasis on Mechanisms of Lyme Borreliosis Persistency

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1995 International Lyme Disease Conference, Vancouver, BC   Opening… John  Millar, MD – Provincial Health Officer, British Columbia Diane Kindree, BSN – Lyme Borreliosis Society of British Columbia Martina H. Ziska, MD – Lyme Disease Foundation James Katzel, MD Ukiah Valley Medical Center No abstract available James H. Oliver, Jr., PhD Callaway Professor of Biology, Director, Institute…

WIDESPREAD DISPERSAL OF BORRELIA BURGDORFERI–INFECTED TICKS COLLECTED [Canada]

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Scott JD, Anderson JF, Durden LA J Parasitol. 2012 Feb;98(1):49-59. Epub  2011 Aug 24. https://www.ncbi.nlm.nih.gov/pubmed/21864130 Abstract Millions of Lyme disease vector ticks are dispersed annually by songbirds across Canada, but often overlooked as the source of infection. For clarity on vector distribution, we sampled 481 ticks (12 species and 3 undetermined ticks) from 211 songbirds…

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Infectious Disease Society of America not ethical, or science based… yet Canada openly endorses them while allowing no victim’s expert input.

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We all have been duped. Infectious Disease [IDSA] Treatment Guidelines Weakened By Paucity of Scientific Evidence Daniel M. Keller, PhD From: Medscape Today November 13, 2009 (Philadelphia, Pennsylvania)— Two separate analyses presented here at the Infectious Diseases Society of America (IDSA) 47th Annual Meeting revealed that most of the society’s treatment guidelines are based on expert…

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Concerns Regarding the Infectious Diseases Society of America Lyme Disease Clinical Practice Guidelines

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Reprints or correspondence: Mr. Jim Wilson, Canadian Lyme Disease Foundation, 2495 Reece Rd., Westbank, BC V4T 1N1, Canada. TO THE EDITOR — The Canadian Lyme Disease Foundation has several concerns with the Infectious Diseases Society of America’s Lyme disease clinical practice guidelines [1]. I shall elaborate. Throughout the guidelines, the erythema migrans rash is referred…