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Featured | Research
Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: A summary of the literature and recent observations.
ByCanLyme Team December 17, 2012April 21, 2023
Rollend L, Fish D, Childs JE. Yale School of Public Health, 60 College Street, New Haven, CT 06520-8034, USA. Electronic address: Lindsay [dot] Rollend [at] yale [dot] edu. Abstract Transovarial transmission (TOT) of Borrelia burgdorferi (sensu lato), the agent of Lyme disease, by the Ixodes persulcatus group of hard ticks (Ixodidae) has frequently been reported…
Read More Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: A summary of the literature and recent observations.
Medical Publications | Research
(case report) Lyme Neuroborreliosis Manifesting as an Intracranial Mass Lesion
ByCanLyme Team December 16, 2012April 21, 2023
Neurosurgery Issue: Volume 30(5), May 1992, p 769-773 Copyright: Copyright (C) by the Congress of Neurological Surgeons Publication Type: [Case Report] ISSN: 0148-396X Accession: 00006123-199205000-00021 Keywords: Lyme disease, Stereotaxis [Case Report] Lyme Neuroborreliosis Manifesting as an Intracranial Mass Lesion Murray, Rhett M.D.; Morawetz, Richard M.D.; Kepes, John M.D.; El Gammal, Taher M.D.; LeDoux, Mark M.D….
Read More (case report) Lyme Neuroborreliosis Manifesting as an Intracranial Mass Lesion
Medical Publications | Research
Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: A summary of the literature and recent observations.
ByCanLyme Team December 15, 2012April 21, 2023
Ticks Tick Borne Dis. 2012 Dec 10. pii: S1877-959X(12)00067-2. doi: 10.1016/j.ttbdis.2012.06.008. [Epub ahead of print] Rollend L, Fish D, Childs JE. Source Yale School of Public Health, 60 College Street, New Haven, CT 06520-8034, USA. Electronic address: Lindsay [dot] Rollend [at] yale [dot] edu Abstract Transovarial transmission (TOT) of Borrelia burgdorferi (sensu lato), the agent…
Read More Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: A summary of the literature and recent observations.
Medical Publications | Research
Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expression.
ByCanLyme Team December 14, 2012April 21, 2023
Kraiczy P, Stevenson B. Source Institute of Medical Microbiology and Infection Control, Frankfurt University Hospital, Paul-Ehrlich-Str. 40, D-60596 Frankfurt, Germany. Electronic address: Kraiczy [at] em [dot] uni-frankfurt [dot] de. Abstract Borrelia burgdorferi, the etiological agent of Lyme disease, exploits an array of strategies to establish infection and to overcome host innate and adaptive immune responses….
Read More Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expression.
Medical Publications | Research
High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete
ByCanLyme Team December 14, 2012April 21, 2023
Abstract Lyme disease, the most common vector-borne zoonosis in North America, is caused by the spirochetal pathogen Borrelia burgdorferi. The telomere resolvase encoded by this organism (ResT) promotes the formation of covalently closed hairpin ends on the linear DNA molecules of B. burgdorferi through a two-step transesterification. ResT is essential for survival and is therefore…
Read More High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete
Medical Publications | Research
Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules.
ByCanLyme Team December 14, 2012April 21, 2023
Mol Microbiol. 2012 Dec;86(5):1116-31. doi: 10.1111/mmi.12045. Epub 2012 Oct 24. Moriarty TJ, Shi M, Lin YP, Ebady R, Zhou H, Odisho T, Hardy PO, Salman-Dilgimen A, Wu J, Weening EH, Skare JT, Kubes P, Leong J, Chaconas G. Source Matrix Dynamics Group, Faculty of Dentistry, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine,…
Read More Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules.
Medical Publications | Research
Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity.
ByCanLyme Team December 14, 2012April 21, 2023
PLoS One. 2012;7(10):e47532. doi: 10.1371/journal.pone.0047532. Epub 2012 Oct 25. Lin T, Gao L, Zhang C, Odeh E, Jacobs MB, Coutte L, Chaconas G, Philipp MT, Norris SJ. Source Department of Pathology and Laboratory Medicine, Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States of America. Abstract The identification of genes…
Read More Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity.
Medical Publications | Research
CSM murray award lecture – functional studies of the Lyme disease spirochete – from molecules to mice.
ByCanLyme Team December 14, 2012April 21, 2023
Abstract Lyme borreliosis, also known as Lyme disease, is now the most common vector transmitted disease in the northern hemisphere. It is caused by the spirochete Borrelia burgdorferi and related species. In addition to their clinical importance, these organisms are fascinating to study because of the wide variety of unusual features they possess. Ongoing work…
Read More CSM murray award lecture – functional studies of the Lyme disease spirochete – from molecules to mice.
Medical Publications | Research
Acute polyradiculoneuritis syndrome: clinical observations and differential diagnosis [important to rule out Lyme disease].
ByCanLyme Team December 13, 2012April 21, 2023
Authors: Supanc V, Stojić I, Vargek-Solter V, Breitenfeld T, Roje-Bedeković M and Demarin V Citation: Acta Clin Croat 2012(Jun); 51(2): 195-9. Location: University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia. visnjasupanc [at] inet [dot] hr Guillain-Barré syndrome (GBS) and neuroborreliosis may clinically manifest with symptoms related to acute polyradiculoneuritis. The aim and…
Read More Acute polyradiculoneuritis syndrome: clinical observations and differential diagnosis [important to rule out Lyme disease].
Research
First isolation of Lyme disease spirochete, Borrelia burgdorferi, from blacklegged tick, Ixodes scapularis, removed from a bird in nova Scotia, Canada.
ByCanLyme Team December 12, 2012April 21, 2023
The Lyme disease spirochete, Borrelia burgdorferi, has been isolated from a blacklegged tick, Ixodes scapularis, removed from a songbird in Canada. On 28 May 1999, this engorged blacklegged tick nymph was removed from a common yellowthroat, Geothlypis trichas, collected during bird banding on Bon Portage Island, Nova Scotia. The Atlantic Bird Observatory participated in collecting…
Read More First isolation of Lyme disease spirochete, Borrelia burgdorferi, from blacklegged tick, Ixodes scapularis, removed from a bird in nova Scotia, Canada.
Miscellaneous | Research
Birds disperse ixodid (Acari: Ixodidae) and Borrelia burgdorferi-infected ticks in Canada
ByCanLyme Team December 12, 2012April 21, 2023
Scott JD, Fernando K, Banerjee SN, Durden LA, Byrne SK, Banerjee M, Mann RB, Morshed MG. Source Lyme Disease Association of Ontario, Fergus, Canada Abstract A total of 152 ixodid ticks (Acari: Ixodidae) consisting of nine species was collected from 82 passerine birds (33 species) in 14 locations in Canada from 1996 to 2000. The…
Read More Birds disperse ixodid (Acari: Ixodidae) and Borrelia burgdorferi-infected ticks in Canada
Miscellaneous
Migratory songbirds disperse ticks across Canada, and first isolation of the Lyme disease spirochete, Borrelia burgdorferi, from the avian tick, Ixodes auritulus.
ByCanLyme Team December 12, 2012April 21, 2023
Abstract During a 3-yr comprehensive study, 196 ixodid ticks (9 species) were collected from 89 passerine birds (32 species) from 25 localities across Canada to determine the distribution of avian-associated tick species and endogenous Lyme disease spirochetes, Borrelia burgdorferi Johnson, Schmid, Hyde, Steigerwalt, and Brenner. We report the following first records of tick parasitism on…
Read More Migratory songbirds disperse ticks across Canada, and first isolation of the Lyme disease spirochete, Borrelia burgdorferi, from the avian tick, Ixodes auritulus.
Medical Publications | Research
Misinformation sent to all Nova Scotia MLA’s and MP’s by Chief Medical Officer of Nova Scotia, Robert Strang.
ByCanLyme Team December 12, 2012April 21, 2023
Here you can read the letter from Dr. Strang at, Strang MLA’s/MP’s followed below by a copy of our reply that was also sent to all Nova Scotia politicians, federal and provincial. Dr. Strang acted in a manner that is contrary to the principles of open science in that he deliberately did not mention the…
Read More Misinformation sent to all Nova Scotia MLA’s and MP’s by Chief Medical Officer of Nova Scotia, Robert Strang.
Medical Publications | Research
Evolving Perspectives on Lyme Borreliosis in Canada
ByCanLyme Team December 11, 2012April 21, 2023
Abstract: With cases now documented in every province, Lyme borreliosis (LB) is emerging as a serious public health risk in Canada. Controversy over the contribution of LB to the burden of chronic disease is maintained by difficulty in capturing accurate Canadian statistics, especially early clinical cases of LB. The use of dogs as sentinel species…
Read More Evolving Perspectives on Lyme Borreliosis in Canada
Medical Publications | Research
Plaques of Alzheimer’s disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete
ByCanLyme Team December 7, 2012April 21, 2023
Summary Here is hypothesized a truly revolutionary notion that rounded cystic forms of Borrelia burgdorferi are the root cause of the rounded structures called plaques in the Alzheimer brain. Rounded ‘‘plaques’ in high density in brain tissue are emblematic of Alzheimer’s disease (AD). Plaques may be conceptualized as rounded ‘‘pock mark-like’’ areas of brain tissue…
Read More Plaques of Alzheimer’s disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete

News and updates

One year later: How the landmark NASEM report on chronic Lyme is – and isn’t – changing minds

Germs spread by ticks and cats found in suicidal youth

Scholarship opportunity for undergraduates with a project focused on Lyme disease or other tick-borne diseases

Living with persistent illness and uncertainty: Patient narratives on Lyme disease in Nova Scotia, Canada

Lyme disease is becoming one of Canada’s defining climate-health challenges

Announcing the second annual Canadian Tick-Borne Disease Conference

Feeling sick after eating that steak dinner? You could have a rare but potentially severe tick-borne allergy

Elliot Jacobson: Downstream Secondary Illness in Lyme Disease

Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: A summary of the literature and recent observations.

(case report) Lyme Neuroborreliosis Manifesting as an Intracranial Mass Lesion

Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: A summary of the literature and recent observations.

Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expression.

High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete

Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules.

Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity.

CSM murray award lecture – functional studies of the Lyme disease spirochete – from molecules to mice.

Acute polyradiculoneuritis syndrome: clinical observations and differential diagnosis [important to rule out Lyme disease].

First isolation of Lyme disease spirochete, Borrelia burgdorferi, from blacklegged tick, Ixodes scapularis, removed from a bird in nova Scotia, Canada.

Birds disperse ixodid (Acari: Ixodidae) and Borrelia burgdorferi-infected ticks in Canada

Migratory songbirds disperse ticks across Canada, and first isolation of the Lyme disease spirochete, Borrelia burgdorferi, from the avian tick, Ixodes auritulus.

Misinformation sent to all Nova Scotia MLA’s and MP’s by Chief Medical Officer of Nova Scotia, Robert Strang.

Evolving Perspectives on Lyme Borreliosis in Canada

Plaques of Alzheimer’s disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete

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