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Medical Publications | Research
Large differences between test strategies for the detection of anti-Borrelia antibodies are revealed by comparing eight ELISAs and five immunoblots.
ByCanLyme Team October 27, 2012April 21, 2023
Ang CW, Notermans DW, Hommes M, Simoons-Smit AM, Herremans T. Source VUMC, Amsterdam, The Netherlands. w [dot] ang [at] vumc [dot] nl Abstract We investigated the influence of assay choice on the results in a two-tier testing algorithm for the detection of anti-Borrelia antibodies. Eighty-nine serum samples from clinically well-defined patients were tested in eight…
Read More Large differences between test strategies for the detection of anti-Borrelia antibodies are revealed by comparing eight ELISAs and five immunoblots.
Medical Publications | Research
Characterization of Biofilm Formation by Borrelia burgdorferi in Vitro
ByCanLyme Team October 27, 2012April 21, 2023
Abstract Borrelia burgdorferi, the causative agent of Lyme disease, has long been known to be capable of forming aggregates and colonies. It was recently demonstrated that Borrelia burgdorferi aggregate formation dramatically changes the in vitro response to hostile environments by this pathogen. In this study, we investigated the hypothesis that these aggregates are indeed…
Read More Characterization of Biofilm Formation by Borrelia burgdorferi in Vitro
International News | Medical Publications | Research
Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity
ByCanLyme Team October 26, 2012April 21, 2023
Tao Lin1*, Lihui Gao1, Chuhua Zhang1, Evelyn Odeh1, Mary B. Jacobs3, Loïc Coutte1¤, George Chaconas4, Mario T. Philipp3, Steven J. Norris1,2 ABSTRACT The identification of genes important in the pathogenesis of Lyme disease Borrelia has been hampered by exceedingly low transformation rates in low-passage, infectious organisms. Using the infectious, moderately transformable B. burgdorferi derivative 5A18NP1…
Read More Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity
International News | Medical Publications | Miscellaneous | News from CanLyme | Research
Spirochetal ‘debris’ versus persistent infection in chronic Lyme disease: from semantics to science.
ByCanLyme October 22, 2012
Lyme disease is a highly controversial illness that features two opposing camps [1–4]. One camp espouses the viewpoint of the International Lyme and Associated Diseases Society (ILADS) that infection with the Lyme spirochete, Borrelia burgdorferi, can be difficult to detect given the current state of diagnostic tests and that the organism can be hard to…
Read More Spirochetal ‘debris’ versus persistent infection in chronic Lyme disease: from semantics to science.
Government | Government reports & letters | Medical Publications | Research
Lyme disease test kits and limitations
ByCanLyme Team October 22, 2012April 21, 2023
Health Canada : “Lyme disease test kits are class II (IV being the highest risk class) in vitro diagnostic devices. The devices are intended for the detection of antibodies to Borrelia burgdorferi in human serum, plasma or cerebrospinal fluid.1 They are used to provide serologic evidence of B. Burgdorferi exposure.1 Infection can result in dermatologic,…
Read More Lyme disease test kits and limitations
Miscellaneous | Research
Spatial stratification of various Lyme disease spirochetes in a Central European site.
ByCanLyme October 17, 2012
Related Articles Spatial stratification of various Lyme disease spirochetes in a Central European site. FEMS Microbiol Ecol. 2012 Oct 12; Authors: Richter D, Schröder B, Hartmann NK, Matuschka FR Abstract To determine whether the genospecies composition of Lyme disease spirochetes is spatially stratified, we collected questing Ixodes ricinus ticks in neighboring plots where rodents, birds…
Read More Spatial stratification of various Lyme disease spirochetes in a Central European site.
Miscellaneous | Research
A Novel Iron- and Copper-Binding Protein in the Lyme Disease Spirochete.
ByCanLyme October 17, 2012
Related Articles A Novel Iron- and Copper-Binding Protein in the Lyme Disease Spirochete. Mol Microbiol. 2012 Oct 15; Authors: Wang P, Lutton A, Olesik J, Vali H, Li X Abstract Iron and copper are transition metals that can be toxic to cells due to their abilities to react with peroxide to generate hydroxyl radical. Ferritins…
Read More A Novel Iron- and Copper-Binding Protein in the Lyme Disease Spirochete.
Featured | Lyme Controversy | Lyme in Alberta | Media | Medical Publications | News from CanLyme | Research
1993, Calgary Herald newspaper … Lyme disease victims tell their story
ByCanLyme Team October 16, 2012March 2, 2025
Lyme disease is not new to Canada, it has been around for centuries. The finding that the Iceman, a 5000 yr old well preserved mummy found in the ice of the Alps, had Lyme disease tells us the Lyme bacteria has been around for millenia. Just don’t tell that to your typical Infectious Disease doctors who…
Read More 1993, Calgary Herald newspaper … Lyme disease victims tell their story
Medical Publications | Research
Diastolic Heart Murmur, Nocturnal Back Pain, and Lumbar Rigidity in a 7-Year Girl: An Unusual Manifestation of Lyme Disease in Childhood
ByCanLyme Team October 13, 2012April 21, 2023
Case Reports in Pediatrics Volume 2012 (2012), Article ID 976961, 3 pagesdoi:10.1155/2012/976961 Case Report Diastolic Heart Murmur, Nocturnal Back Pain, and Lumbar Rigidity in a 7-Year Girl: An Unusual Manifestation of Lyme Disease in Childhood Genn Kameda,1 Silvia Vieker,1 Johannes Hartmann,2 Tim Niehues,3 and Alfred Längler4 1 Department for Child and Adolescent Health, Gemeinschaftskrankenhaus, Gerhard-Kienle…
Read More Diastolic Heart Murmur, Nocturnal Back Pain, and Lumbar Rigidity in a 7-Year Girl: An Unusual Manifestation of Lyme Disease in Childhood
Featured | Medical Publications | Research
Evolving Perspectives on Lyme Borreliosis in Canada
ByCanLyme Team October 11, 2012April 21, 2023
J.L.H. Sperling1,2, M.J. Middelveen2, D. Klein3, and F.A.H. Sperling*,1 1Department of Biological Sciences, University of Alberta, Edmonton, Canada 2Canadian Lyme Disease Foundation, West Kelowna, British Columbia, Canada 3Department of Family Medicine, University of Alberta, Edmonton, Canada Abstract: With cases now documented in every province, Lyme borreliosis (LB) is emerging as a serious public health risk…
Read More Evolving Perspectives on Lyme Borreliosis in Canada
Medical Publications | Research
The Lymphocyte Transformation Test for Borrelia Detects Active Lyme Borreliosis and Verifies Effective Antibiotic Treatment
ByCanLyme Team October 11, 2012April 21, 2023
Volker von Baehr, Cornelia Doebis, Hans-Dieter Volk, Rüdiger von Baehr Published Date: (05 October, 2012) Borrelia-specific antibodies are not detectable until several weeks after infection and even if they are present, they are no proof of an active infection. Since the sensitivity of culture and PCR for the diagnosis or exclusion of borreliosis is too…
Read More The Lymphocyte Transformation Test for Borrelia Detects Active Lyme Borreliosis and Verifies Effective Antibiotic Treatment
For Physicians | Medical Publications | Research
Chronic or Late Lyme Neuroborreliosis: Present and Future
ByCanLyme Team October 11, 2012April 21, 2023
Judith Miklossy*, Samuel Donta, Kurt Mueller, Oliver Nolte and George Perry Alzheimer Research Center, Prevention Alzheimer International Foundation, 1921 Martigny-Croix, CP 16, Switzerland This special issue gives a framework of an international effort, to critically and constructively overview the clinical and pathological aspects of Lyme neuroborreliosis and show directions for future practice and research. The…
Read More Chronic or Late Lyme Neuroborreliosis: Present and Future
For Physicians | Medical Publications | Research
A Reappraisal of the U.S. Clinical Trials of Post-Treatment Lyme Disease Syndrome
ByCanLyme Team October 11, 2012April 21, 2023
Brian A. Fallon, Eva Petkova, John G. Keilp and Carolyn B. Britton Published Date: (05 October, 2012) Four federally funded randomized placebo-controlled treatment trials of post-treatment Lyme syndrome in the United States have been conducted. Most international treatment guidelines summarize these trials as having shown no acute or sustained benefit to repeated antibiotic therapy. The…
Read More A Reappraisal of the U.S. Clinical Trials of Post-Treatment Lyme Disease Syndrome
Medical Publications | Research
The Psychoimmunology of Lyme/Tick-Borne Diseases and its Association with Neuropsychiatric Symptoms
ByCanLyme Team October 11, 2012April 21, 2023
Robert C. Bransfield* Abstract: Disease progression of neuropsychiatric symptoms in Lyme/tick-borne diseases can be better understood by greater attention to psychoimmunology. Although there are multiple contributors that provoke and weaken the immune system, infections and persistent infections are significant causes of pathological immune reactions. Immune mediated ef-fects are a significant contributor to the pathophysiological processes…
Read More The Psychoimmunology of Lyme/Tick-Borne Diseases and its Association with Neuropsychiatric Symptoms
Lyme in BC | Medical Publications | Miscellaneous | Research
Vancouver, BC: 8th Annual LDF International Scientific Conference on Lyme Borreliosis and other Spirochetal and Tick-borne Diseases: with an emphasis on Mechanisms of Lyme Borreliosis Persistency
ByCanLyme Team September 28, 2012April 21, 2023
1995 International Lyme Disease Conference, Vancouver, BC Opening… John Millar, MD – Provincial Health Officer, British Columbia Diane Kindree, BSN – Lyme Borreliosis Society of British Columbia Martina H. Ziska, MD – Lyme Disease Foundation James Katzel, MD Ukiah Valley Medical Center No abstract available James H. Oliver, Jr., PhD Callaway Professor of Biology, Director, Institute…
Read More Vancouver, BC: 8th Annual LDF International Scientific Conference on Lyme Borreliosis and other Spirochetal and Tick-borne Diseases: with an emphasis on Mechanisms of Lyme Borreliosis Persistency

Research

Large differences between test strategies for the detection of anti-Borrelia antibodies are revealed by comparing eight ELISAs and five immunoblots.

Characterization of Biofilm Formation by Borrelia burgdorferi in Vitro

Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity

Spirochetal ‘debris’ versus persistent infection in chronic Lyme disease: from semantics to science.

Lyme disease test kits and limitations

Spatial stratification of various Lyme disease spirochetes in a Central European site.

A Novel Iron- and Copper-Binding Protein in the Lyme Disease Spirochete.

1993, Calgary Herald newspaper … Lyme disease victims tell their story

Diastolic Heart Murmur, Nocturnal Back Pain, and Lumbar Rigidity in a 7-Year Girl: An Unusual Manifestation of Lyme Disease in Childhood

Evolving Perspectives on Lyme Borreliosis in Canada

The Lymphocyte Transformation Test for Borrelia Detects Active Lyme Borreliosis and Verifies Effective Antibiotic Treatment

Chronic or Late Lyme Neuroborreliosis: Present and Future

A Reappraisal of the U.S. Clinical Trials of Post-Treatment Lyme Disease Syndrome

The Psychoimmunology of Lyme/Tick-Borne Diseases and its Association with Neuropsychiatric Symptoms

Vancouver, BC: 8th Annual LDF International Scientific Conference on Lyme Borreliosis and other Spirochetal and Tick-borne Diseases: with an emphasis on Mechanisms of Lyme Borreliosis Persistency

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