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“Aug 19, 2022 Dr Embers shares insights from her research program into Lyme disease at Tulane National Primate Research Center. By transmitting Lyme disease to mice and nonhuman primates by tick, and studying the natural course of infection, Dr Embers’ group aims to attain a better understanding of the clinical quandaries of human Lyme disease,…
The complex etiology of neurodegenerative disease has prompted studies on multiple mechanisms including genetic predisposition, brain biochemistry, immunological responses, and microbial insult. In particular, Lyme disease is often associated with neurocognitive impairment with variable manifestations between patients. We sought to develop methods to reliably detect Borrelia burgdorferi, the spirochete bacteria responsible for Lyme disease, in autopsy…
Oct. 2020 PLOS PATHOGENS Abstract Borrelia burgdorferi, the Lyme disease pathogen causes persistent infection by evading the host immune response. Differential expression of the surface-exposed lipoprotein VlsE that undergoes antigenic variation is a key immune evasion strategy employed by B. burgdorferi. Most studies focused on the mechanism of VlsE antigen variation, but little is known…
Parasites & Vectors 2019 12:237 Natalie Rudenko; Maryna Golovchenko; Katerina Kybicova and Marie Vancova Published May 16, 2019 Abstract The survival of spirochetes from the Borrelia burgdorferi (sensu lato) complex in a hostile environment is achieved by the regulation of differential gene expression in response to changes in temperature, salts, nutrient content, acidity fluctuation, multiple host or vector dependent factors, and leads to the…
DOI: https://dx.doi.org/10.1016/j.ajpath.2017.11.005 Nicholas A. Crossland, Xavier Alvarez, Monica E. Embers Abstract Non-human primates currently serve as the best experimental model for Lyme disease due to their close genetic homology with humans and demonstration of all three phases of disease following infection with Borreliella (Borrelia) burgdorferi (Bb). We investigated the pathology associated with late disseminated Lyme disease (12 to…
[CanLyme note: Currently, testing and symptomotology knowledge are not nearly accurate enough to distinguish between a human B. hermsii infection and a B.burgdorferi infection yet many people are told they do not have a treatable borreliosis simply because they do not have a positive Borrelia burgdorferi strain B31 when we have many other borrelia, and some we…
