Tag Archives: persistent infection

Metamorphoses of Lyme disease spirochetes: phenomenon of Borrelia persisters

Parasites & Vectors 2019 12:237 Natalie Rudenko; Maryna Golovchenko; Katerina Kybicova and Marie Vancova Published May 16, 2019 Abstract The survival of spirochetes from the Borrelia burgdorferi (sensu lato) complex in a hostile environment is achieved by the regulation of differential gene expression in response to changes in temperature, salts, nutrient content, acidity fluctuation, multiple host or vector dependent factors, and leads to the formation of dormant subpopulations of Continues →

Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in Rhesus Macaques

DOI: http://dx.doi.org/10.1016/j.ajpath.2017.11.005 Nicholas A. Crossland, Xavier Alvarez, Monica E. Embers Abstract Non-human primates currently serve as the best experimental model for Lyme disease due to their close genetic homology with humans and demonstration of all three phases of disease following infection with Borreliella (Borrelia) burgdorferi (Bb). We investigated the pathology associated with late disseminated Lyme disease (12 to 13 months following tick inoculation) Continues →

The Borrelia hermsii factor H binding protein FhbA is not required for infectivity in mice or for resistance to human complement in vitro.

[CanLyme note: Currently, testing and symptomotology knowledge are not nearly accurate enough to distinguish between a human B. hermsii infection and a B.burgdorferi infection yet many people are told they do not have a treatable borreliosis simply because they do not have a positive Borrelia burgdorferi strain B31 when we have many other borrelia, and some we have not identified yet.] Infect Continues →