High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete

BySherwin Arnott

Abstract Lyme disease, the most common vector-borne zoonosis in North America, is caused by the spirochetal pathogen Borrelia burgdorferi. The telomere resolvase encoded by this organism (ResT) promotes the formation of covalently closed hairpin ends on the linear DNA molecules of B. burgdorferi through a two-step transesterification. ResT is essential for survival and is therefore…

Prevent Lyme Disease with Showers and Fences [Yale study]

BySherwin Arnott

Infection can cause complications if not treat early, but research suggests you can prevent Lyme disease with some simple tactics. RODALE NEWS, EMMAUS, PA—In the Northeastern United States, the place where you’re most likely to be bitten by a tick carrying Lyme disease is not in the woods, but in your own backyard. Fortunately, research…

Biofilms: A New Hideout for Borrelia burgdorferi?

BySherwin Arnott

The University of New Haven established a Lyme Disease Research group six years ago. To date, over forty graduate students have received training in Lyme disease related research. One of our recent projects studies the different formations of Borrelia burgdorferi, the Lyme disease bacteria. With coauthor Dr. Alan MacDonald, we recently suggested that Borrelia burgdorferi…

Multilocus sequence analysis of Borrelia bissettii strains from North America reveals a new Borrelia species, Borrelia kurtenbachii

BySherwin Arnott

Gabriele Margos,a,* Andrias Hojgaard,b Robert S. Lane,c Muriel Cornet,d Volker Fingerle,e Nataliia Rudenko,f Nicholas Ogden,g David M. Aanensen,h Durland Fish,i and Joseph Piesman,b Abstract Using multilocus sequence analyses (MLSA), we investigated the phylogenetic relationship of spirochaete strains from North America previously assigned to the genospecies Borrelia bissettii. We amplified internal fragments of 8 housekeeping genes…

Humans Infected with Relapsing Fever Spirochete Borrelia miyamotoi, Russia

BySherwin Arnott

Abstract Borrelia miyamotoi is distantly related to B. burgdorferi and transmitted by the same hard-body tick species. We report 46 cases of B. miyamotoi infection in humans and compare the frequency and clinical manifestations of this infection with those caused by B. garinii and B. burgdorferi infection. All 46 patients lived in Russia and had…

Detection of Borrelia bissettii in cardiac valve tissue of a patient with endocarditis and aortic valve stenosis in the Czech Republic.

BySherwin Arnott

Nataliia Rudenko Maryna Golovchenko Aleš Mokráček Natalja Piskunová Daniel Růžek Nadja Mallatová Libor Grubhoffer ABSTRACT Molecular analysis of a clinical sample confirmed the presence of Borrelia bissettii DNA in cardiac valve tissue from a patient with endocarditis and aortic valve stenosis. This evidence strongly supports the involvement of B. bissettii in Lyme disease in Europe. Read…

Tuskegee Part 2 – Lyme disease – A far larger fraud?

BySherwin Arnott

The Tuskgegee experiment that started in the 1930’s ruined over 600 people’s lives who had syphilis, a spirochetal infection like Lyme disease who unknowlingly had antibiotics withheld from them by being given placebos. “The Tuskegee Syphilis Study, cited as “arguably the most infamous biomedical research study in U.S. history,” ” Here in this speech, Lyme disease is said…

British Columbia government report on Lyme disease – Schmidt report

BySherwin Arnott

After much negative media attention in 2008 relative to the poor quality of health care relating to Lyme disease in BC, the provincial Minister of Health and Deputy Minister of Health had to act. Also, that year questions posed by the opposition critic David Cubberley to the Minister of Health proved to be difficult for…