[Canlyme note: Although Borrelia are not known to secrete toxins, this type of research may be beneficial for chemical constituents such as borrelia lipoproteins and lipopolysaccharides.]
November 4th, 2014 Published online
Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice
Abstract
Gram-positive bacterial pathogens that secrete cytotoxic pore-forming toxins, such as Staphylococcus aureus and Streptococcus pneumoniae, cause a substantial burden of disease. Inspired by the principles that govern natural toxin-host interactions, we have engineered artificial liposomes that are tailored to effectively compete with host cells for toxin binding. Liposome-bound toxins are unable to lyse mammalian cells in vitro. We use these artificial liposomes as decoy targets to sequester bacterial toxins that are produced during active infection in vivo. Administration of artificial liposomes within 10 h after infection rescues mice from septicemia caused by S. aureusand S. pneumoniae, whereas untreated mice die within 24–33 h. Furthermore, liposomes protect mice against invasive pneumococcal pneumonia. Composed exclusively of naturally occurring lipids, tailored liposomes are not bactericidal and could be used therapeutically either alone or in conjunction with antibiotics to combat bacterial infections and to minimize toxin-induced tissue damage that occurs during bacterial clearance.
by Daniel J. Cameron, MD MPH “Although rare, sudden cardiac death caused by Lyme disease might be an under-recognized entity,” according to researchers who describe their findings from an autopsy study on 5 case patients who died from sudden cardiac death and were found post mortem to have Lyme carditis. The cases are discussed in…
Encourage your physician to attend!! Speakers will be… Dr. Ralph Hawkins, Internal Medicine specialist, Calgary, AB Dr. Tim Cook, Internal Medicine specialist, Toronto, ON Melanie Wills, PhD, scientist and lead researcher at the G. Magnotta Foundation for Vector Borne Diseases Research Lab, University of Guelph. Sue Faber R.N, BSc.N and Jennifer Kravis B.A,LL.B. Co-founders of LymeHope….
[CanLyme note: Many parents with autistic children who have also received treatment for a Lyme disease infection report similar amazing results from antibiotic treatment leading to hypotheses that some autism may be an infectious disease origin.] Brian Cross, Windsor Star, published February 12th, 2016 A five-year-old boy with autism who has never really communicated, has suddenly started answering back…
The debilitating tick-borne disease is well-documented north of the Mason-Dixon line, but does it exist beyond that? By Wendy Orent, Friday, November 01, 2013 Kerry Clark never wanted to show that Lyme disease exists in the Southern United States by catching it himself. Clark is a medical entomologist at the University of North Florida in Jacksonville….
“Dr. Charles Ray Jones, a trailblazing pediatric Lyme specialist who has treated more than 15,000 children from around the world for tick-borne diseases, has died.” Access article
Abstract Introduction The etiology of Parkinson’s disease (PD) remains unclear. The aim of this study was to examine the association between common pathogenic infections and PD. Methods Antibody titers to common infectious pathogens including cytomegalovirus (CMV), Epstein Barr virus (EBV), herpes simplex virus type-1 (HSV-1), Borrelia burgdorferi (B. burgdorferi), Chlamydophila pneumoniae (C. pneumoniae) andHelicobacter pylori…
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