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Harvard study identifies symptom clusters in Lyme patients with persistent symptoms

ByCanLyme Team

A retrospective study of 270 post-treatment Lyme patients identified the most debilitating neurological symptoms, paving the way for future studies on root causes of disease and better treatments. The largest study to-date characterizing ongoing symptoms [1] of Lyme patients after antibiotic treatment has been published by a group of investigators at Harvard-affiliated hospitals and Invisible International, a non-profit organization….

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When Lyme Disease Doesn’t Go Away

ByCanLyme Team

[CanLyme Note: The term “post-treatment” is misleading because it implies effective treatment was given when in fact it was not, because it was too short in duration, dosage, or the wrong antibiotic or antibiotic combination for that person.] iIt’s tick season. Here’s what Brian Fallon, the director of Columbia’s Lyme & Tick-borne Diseases Research Center,…

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Hide and Seek: How Lyme Disease Spirochetes Overcome Complement Attack

ByTeam

Peter Kraiczy* Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Frankfurt am Main, Germany Overcoming the first line of the innate immune system is a general hallmark of pathogenic microbes to avoid recognition and to enter the human host. In particular, spirochetes belonging to the Borrelia burgdorferi sensu lato complex have developed…

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Illuminating the roles of the Borrelia burgdorferi adhesins

ByTeam

The Lyme disease spirochetes, Borrelia burgdorferi (sensu lato), must cause persistent, disseminated infection to be maintained in the natural enzootic cycle. In human Lyme disease, spirochetes spread from the site of a tick bite to colonize multiple tissue sites, causing multisystem clinical manifestations. The Lyme spirochetes produce many adhesive surface proteins that collectively recognize diverse host substrates…