Tag Archives: persistent

When Lyme Disease Doesn’t Go Away

[CanLyme Note: The term “post-treatment” is misleading because it implies effective treatment was given when in fact it was not, because it was too short in duration, dosage, or the wrong antibiotic or antibiotic combination for that person.] iIt’s tick season. Here’s what Brian Fallon, the director of Columbia’s Lyme & Tick-borne Diseases Research Center, has to say about combating Continues →

Hide and Seek: How Lyme Disease Spirochetes Overcome Complement Attack

Peter Kraiczy* Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Frankfurt am Main, Germany Overcoming the first line of the innate immune system is a general hallmark of pathogenic microbes to avoid recognition and to enter the human host. In particular, spirochetes belonging to the Borrelia burgdorferi sensu lato complex have developed various means to counter the Continues →

Illuminating the roles of the Borrelia burgdorferi adhesins

The Lyme disease spirochetes, Borrelia burgdorferi (sensu lato), must cause persistent, disseminated infection to be maintained in the natural enzootic cycle. In human Lyme disease, spirochetes spread from the site of a tick bite to colonize multiple tissue sites, causing multisystem clinical manifestations. The Lyme spirochetes produce many adhesive surface proteins that collectively recognize diverse host substrates and cell types and are Continues →