Study: Current and emerging approaches for alleviating persistent Lyme disease
Prevention and the need for better diagnostic tools also recognized by researchers.
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Hitchhiker’s Guide to Borrelia burgdorferi – an excellent backgrounder on Lyme disease for biologists
By the end of the review, you may discover that you have more in common with the bemused Arthur Dent than you might have expected.
Protein found in human sweat inhibits growth of Lyme bacteria
Satu Strausz of Finland leads international group exploring biobank, in vitro, and murine research.
Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination
Using genetic association study methods, we identify an accessory genome signature associated with dissemination in humans and define the individual plasmids and genes that make up this signature.
- Education | For Physicians | Lyme Controversy | Lyme disease | Medical Publications | Miscellaneous | Research
Children are more than twice as likely to lose their detectable antibodies to Lyme disease bacteria
Background Lyme borreliosis (LB), caused by Borrelia burgdorferi (Bb), is the most common tick-borne infection in Germany. Antibodies against Bb are prevalent in the general population but information on temporal changes of prevalence and estimates of seroconversion (seroincidence) and seroreversion are lacking, especially for children and adolescents. Aim We aimed at assessing antibodies against Bb and factors associated with seropositivity…
Borrelia burgdorferi and Borrelia miyamotoi in Atlantic Canadian wildlife
Abstract Borrelia burgdorferi and Borrelia miyamotoi are tick-vectored zoonotic pathogens maintained in wildlife species. Tick populations are establishing in new areas globally in response to climate change and other factors. New Brunswick is a Canadian maritime province at the advancing front of tick population establishment and has seen increasing numbers of ticks carrying B. burgdorferi, and more recently B. miyamotoi. Further, it…
Transgenic functional complementation with a transmission -associated protein restores spirochete infectivity by tick bite
Abstract The relapsing fever spirochete Borrelia hermsii and the Lyme disease spirochete Borrelia burgdorferi sensu stricto each produces an abundant, orthologous, outer membrane protein, Vtp and OspC, respectively, when transmitted by tick bite. Gene inactivation studies have shown that both proteins are essential for spirochete infectivity when transmitted by their respective tick vectors. Therefore, we transformed a vtp-minus mutant of B….
Lyme disease in children: Data from the Canadian Paediatric Surveillance Program
Online November 30th, 2019 Abstract BACKGROUND: Lyme disease (LD) is an infectious disease that is emerging in eastern and central Canada associated with the spread of the tick vector Ixodes scapularis. National surveillance shows that children are an at-risk age group. OBJECTIVES: To study the epidemiology of LD in Canadian children using the Canadian Paediatric Surveillance Program (CPSP) to better…
The association between infectious burden and Parkinson’s disease: A case-control study
Abstract Introduction The etiology of Parkinson’s disease (PD) remains unclear. The aim of this study was to examine the association between common pathogenic infections and PD. Methods Antibody titers to common infectious pathogens including cytomegalovirus (CMV), Epstein Barr virus (EBV)，herpes simplex virus type-1 (HSV-1), Borrelia burgdorferi (B. burgdorferi), Chlamydophila pneumoniae (C. pneumoniae) and Helicobacter pylori (H. pylori) were measured by ELISA in serum…
Metamorphoses of Lyme disease spirochetes: phenomenon of Borrelia persisters
Parasites & Vectors 2019 12:237 Natalie Rudenko; Maryna Golovchenko; Katerina Kybicova and Marie Vancova Published May 16, 2019 Abstract The survival of spirochetes from the Borrelia burgdorferi (sensu lato) complex in a hostile environment is achieved by the regulation of differential gene expression in response to changes in temperature, salts, nutrient content, acidity fluctuation, multiple host or vector dependent factors, and leads to the…
Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques
Marianne J Middelveen, Iris Du Cruz, Melissa C Fesler, Raphael B Stricker, Jyotsna S Shah 1Atkins Veterinary Services, Calgary, AB, Canada; 2IGeneX Laboratories, Palo Alto, CA, USA; 3Union Square Medical Associates, San Francisco, CA, USA Background: Morgellons disease (MD) is a skin condition associated with Lyme disease (LD) and tick-borne illness. Patients with this skin disorder experience ulcerative lesions that contain multicolored…
- Co-infections | For Physicians | Lyme Controversy | Medical Publications | Miscellaneous | Research | Voices on Lyme
History of Morgellons disease: from delusion to definition
Middelveen, et al https://doi.org/10.2147/CCID.S152343 Abstract: Morgellons disease (MD) is a skin condition characterized by the presence of multicolored filaments that lie under, are embedded in, or project from skin. Although the condition may have a longer history, disease matching the above description was first reported in the US in 2002. Since that time, the condition that…
- For Physicians | Lyme Controversy | Medical Publications | Miscellaneous | Research | Voices on Lyme
Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease
M. Middelveen, et al. PREPRINT Abstract Introduction: Lyme disease is a tickborne illness that generates controversy among medical providers and researchers. One of the key topics of debate is the existence of persistent infection with the Lyme spirochete, Borrelia burgdorferi, in patients who have been treated with recommended doses of antibiotics yet remain symptomatic. Persistent spirochetal infection…
Empirical validation of the Horowitz Multiple Systemic Infectious Disease Syndrome Questionnaire for suspected Lyme disease
International Journal of General Medicine September 4th, 2017 Purpose: Lyme disease is spreading worldwide, with multiple Borrelia species causing a broad range of clinical symptoms that mimic other illnesses. A validated Lyme disease screening questionnaire would be clinically useful for both providers and patients. Three studies evaluated such a screening tool, namely the Horowitz Multiple…
- For Physicians | Lyme Controversy | Lyme in Ontario | Medical Publications | Miscellaneous | Research
Detection of Lyme Disease Bacterium, Borrelia burgdorferi sensu lato, in Blacklegged Ticks Collected in the Grand River Valley, Ontario, Canada
Scott et al. Received: 2016.09.29; Accepted: 2016.12.28; Published: 2017.02.08 Abstract We document the presence of blacklegged ticks, Ixodes scapularis, in the Grand River valley, Centre Wellington, Ontario. Overall, 15 (36%) of 42 I. scapularis adults collected from 41 mammalian hosts (dogs, cats, humans) were positive for the Lyme disease bacterium, Borrelia burgdorferi sensu lato (s.l.)….
