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Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Microcolony B. burgdorferi Persisters Which Are Sterilized by Daptomycin/ Doxycycline/Cefuroxime without Pulse Dosing

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Published Nov 2016 Abstract   Although the majority of Lyme disease patients can be cured, at least 10–20% of the patients continue to suffer from persisting symptoms such as fatigue, muscular and joint pain, and neurologic impairment after standard 2–4 week antibiotic treatment. While the causes for this post-treatment Lyme disease symptoms are unclear, one…

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Drexel University Team Duplicates Dr Alan MacDonald’s Findings of Bacterial Biofilms in Alzheimer’s Plaques

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Feb. 2016   –  Allen et al., J Neuroinfect Dis 2016, 7:1 Dr. Herbert B. Allen and his colleagues at Drexel University, Philadelphia have confirmed the presence of bacterial biofilm substance in autopsy brain tissue from victims of Alzheimer’s disease. The extracellular polysaccharide matrix of the biofilms was detected using periodic acid Schiff (PAS) stain,…

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Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi

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Background: Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi. Although antibiotic therapy is usually effective early in the disease, relapse may occur when administration of antibiotics is discontinued. Studies have suggested that resistance and recurrence of Lyme disease might be due to formation of different morphological forms of B. burgdorferi, namely…

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Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro

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Abstract   Borrelia burgdorferi, the causative agent of Lyme disease, has long been known to be capable of forming aggregates and colonies. It was recently demonstrated that Borrelia burgdorferi aggregate formation dramatically changes the in vitro response to hostile environments by this pathogen. In this study, we investigated the hypothesis that these aggregates are indeed…