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Evidence of in vivo existence of Borrelia biofilm in borrelial lymphocytomas

DOI: https://dx.doi.org/10.1556/1886.2015.00049 Abstract Lyme borreliosis, caused by the spirochete Borrelia burgdorferi sensu lato, has grown into a major public health problem. We recently identified a novel morphological form of B. burgdorferi, called biofilm, a structure that is well known to be highly resistant to antibiotics. However, there is no evidence of the existence ofBorrelia biofilm…

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Watch interview of Prof Ying Zhang on Borrelia persisters

Interview with Prof. Ying Zhang at the NorVect Conference 2015   Published on Sep 29, 2015 Prof Ying Zhang from John Hopkins Bloomberg School of Public Health explains why Lyme disease is so difficult to treat. Having worked with Tuberculosis (TB) for many years, he sees the similarities and differences between these to bacteria. With…

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The Scientist: The Search for Persisters

It starts with a tick bite. This may be followed by the characteristic bullseye rash. And then the other symptoms of Lyme disease appear. Fever, fatigue, body aches, and headaches can all set in. For most patients diagnosed with Lyme disease, the symptoms fade as the infection is cleared following a course of antibiotics. But…

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Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treatment in Mice

 Emir Hodzic, Denise Imai, Sunlian Feng, Stephen W. Barthold Published: January 23, 2014 Abstract   The agent of Lyme borreliosis, Borrelia burgdorferi, evades host immunity and establishes persistent infections in its varied mammalian hosts. This persistent biology may pose challenges to effective antibiotic treatment. Experimental studies in dogs, mice, and non-human primates have found persistence of B. burgdorferi DNA following treatment…


Persistence of the Lyme Disease Spirochete

Many thanks to researcher John D. Scott of the Lyme Disease Association of Ontario for providing this valuable and comprehensive list. The following references for persistence of Lyme disease (Lyme borreliosis) are listed alphabetically and then chronologically for the author of more than one publication:  Aalto A, Sjowall J, Davidsson L, Forsberg P, Smedby O….