Spirochetes causing Lyme borreliosis are obligate parasites that can only be found in a tick vector or a vertebrate host. The ability to survive in these two disparate environments requires up and downregulation of specific genes by regulatory circuits that remain largely obscure.
Categories for Research
Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase.
Persistent infection by pathogenic organisms requires effective strategies for the defense of these organisms against the host immune response.
Here we investigate the dynamics of the hepatic intravascular immune response to a pathogen relevant to invariant natural killer T cells (iNKT cells).
Detection of Lyme disease spirochete, Borrelia burgdorferi sensu lato, including three novel genotypes in ticks (Acari: Ixodidae) collected from songbirds (Passeriformes) across Canada
The source of sporadic Lyme disease (Lyme borreliosis) across Canada has been a mystery. Several tenets abound about the origin of this bacterial illness, but science is often lacking.
Scott JD, Anderson JF, Durden LA J Parasitol 2011 08 24 Abstract Millions of Lyme disease vector ticks are dispersed... View Article
Benjamin Luft, M.D., Professor of Medicine, Stony Brook University Medical Center, and a team of medical researchers have determined the genetic blueprint of 13 strains of the bacteria that cause Lyme disease. The finding is crucial to advancing research on Lyme disease, the most frequent tick-borne infection in North America and Europe, and may lead to better diagnostics and a vaccine
Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease.
CSM Murray Award Lecture – Functional studies of the Lyme disease spirochete – from molecules to mice
Department of Biochemistry & Molecular Biology, and Department of Microbiology & Infectious Diseases, University of Calgary
Assessment of the microbial diversity residing in arthropod vectors of medical importance is crucial for monitoring endemic infections, for surveillance of newly emerging zoonotic pathogens, and for unraveling the associated bacteria within its host.
Human granulocytic anaplasmosis (HGA) is an emerging tick-borne disease in China. A cluster of cases among health care workers and family members following exposure to a patient with fulminant disease consistent with HGA prompted investigation.
The objective of the follow-up study was to determine the long-term outcome of strictly classified cases of neuroborreliosis treated with antibiotics.
The Lyme disease spirochete, Borrelia burgdorferi, is an extracellular microbe that causes persistent infection despite the development of strong immune responses against the bacterium.
My research focuses on the functions of phagocytic cells, both macrophages and neutrophils, and their interaction with the Lyme disease spirochete, Borrelia burgdorferi. We are exploring the paradox of spirochete persistence in vivo despite rapid and efficient killing by phagocytes in vitro.
University scientists have made a key advance in understanding the proteins and mechanisms involved in the spread of Lyme disease, a finding that could lead to a vaccine against the tick-borne illness that affects thousands of people each year.
As world leaders gather in Copenhagen at the United Nations Climate Change conference, animal health experts warn of the potential impact of global warming on family pets.