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Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination

Abstract Lyme disease is the most common vector-borne disease in North America and Europe. The clinical manifestations of Lyme disease vary based on the genospecies of the infecting Borrelia burgdorferi spirochete, but the microbial genetic elements underlying these associations are not known. Here, we report the whole genome sequence (WGS) and analysis of 299 B. burgdorferi (Bb) isolates derived from…

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Pathogenic analysis of Borrelia garinii strain SZ isolated from northeastern China

BACKGROUND: Various genospecies of Borrelia burgdorferi sensu lato (s.l.) have been identified from patients and animals worldwide. Genospecies-related dissemination of disease has been reported. The present study aimed to elucidate the pathogenicity of infections caused by B. garinii SZ isolated in China. B. burgdorferi B31 and B. afzelii BO23 were used for comparison. METHODS: Spirochete…

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The Early Dissemination Defect Attributed to Disruption of Decorin-Binding Proteins Is Abolished in Chronic Murine Lyme Borreliosis

doi: 10.1128/IAI.01359-12 Infect. Immun. May 2013 vol. 81 no. 5 1663-1673    Denise M. Imaia, D. Scott Samuelsb, Sunlian Fenga, Emir Hodzica, Kim Olsena and Stephen W. Bartholda Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis, Davis, California, USAa Division of Biological Sciences, The University of Montana, Missoula, Montana, USAb R. P. Morrison, Editor + Author…