An Unusual Cluster of Neuroinvasive Lyme Disease Cases Presenting With Bannwarth Syndrome in the Midwest United States

[CanLyme note:  This statement, “Garin-Bujadoux-Bannwarth syndrome (Bannwarth syndrome [BWS]) is an uncommon manifestation of neuroinvasive Lyme disease (LD) caused by infection with members of Borrelia burgdorferi sensu lato (Bbsl)” indicates BWS in an uncommon manifestation of Lyme disease but may suggest it is a rarely connected manifestation of Lyme borreliosis.]
Published: 23 December 2017

Abstract

Bannwarth syndrome (BWS), an infrequent manifestation of neuroinvasive Lyme disease (LD) characterized by radiculopathy, neuropathy, and lymphocytic pleocytosis, is more commonly documented in Europe than North America. Here, we describe a cluster of 5 neuroinvasive LD cases with BWS in the upper Midwest United States between July and August 2017…. Garin-Bujadoux-Bannwarth syndrome (Bannwarth syndrome [BWS]) is an uncommon manifestation of neuroinvasive Lyme disease (LD) caused by infection with members of Borrelia burgdorferi sensu lato (Bbsl) complex and is more frequently described in patients with Lyme disease in Europe as compared with the United States [1]. BWS is characterized by painful radiculopathy, neuropathy, varying degrees of motor weakness and facial nerve palsy, and cerebrospinal fluid (CSF) lymphocytic pleocytosis.Over 3 weeks between July and August 2017, Mayo Clinic campuses in Minnesota and Wisconsin identified 6 patients from the upper Midwest with Lyme neuroborreliosis (LNB), 5 presenting with BWS. Here, we present the findings of these 5 patients.

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