Tag Archives: mice

Mouse genome unraveled. Perhaps new strategies to curtail the proliferation of tick-borne and other infectious diseases.

The genome of Peromyscus leucopus, natural host for Lyme disease and other emerging infections July 24, 2019 Abstract   The rodent Peromyscus leucopus is the natural reservoir of several tick-borne infections, including Lyme disease. To expand the knowledge base for this key species in life cycles of several pathogens, we assembled and scaffolded the P. leucopus genome. The resulting assembly was 2.45 Gb in total Continues →

Chronic persistent late Lyme disease not a new phenomenon

Chronic Lyme borreliosis in the laboratory mouse. Am J Pathol. 1993 Sep; 143(3): 959–971 Abstract C3H/HeJ mice were inoculated intraperitoneally with 10(7) uncloned Borrelia burgdorferi at 4 weeks of age and examined on days 30, 90, 180, and 360. Spirochetes were isolated from multiple tissues at all intervals. Joint and heart disease were present in all mice at 30 days Continues →

Squirrels ‘host Lyme disease bugs’

Tuesday 21 April 2015 Grey squirrels are in the dock again – this time for harbouring a serious infection that can be spread to humans by ticks. The American immigrant rodents already have previous convictions for decimating native red squirrel populations and damaging woodland by stripping bark from trees. Grey squirrels host the bacteria responsible for Lyme disease, it has Continues →

The immune system cannot generate immunological memory during infection with the Lyme disease agent B. burgdorfer

R.A. Elsner, S.W. Barthold, N. Baumgarth http://www.sciencedirect.com/science/article/pii/S1043466613003542 Graduate Group in Microbiology and the Center for Comparative Medicine, University of California-Davis, Davis, CA, USA In vertebrates including humans, mice and dogs, the bacteria Borrelia burgdorferi (Bb) causes a chronic, non-resolving infection known as Lyme disease, which requires antibiotic treatment to clear the bacteria. Re-infections are common in endemic regions. Similarly, mice Continues →