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Dynamics of connective-tissue localization during chronic Borrelia burgdorferi infection

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Laboratory Investigation , (24 June 2013) | doi :10.1038/labinvest.2013.81 Denise M Imai, Sunlian Feng, Emir Hodzic and Stephen W Barthold Abstract The etiologic agent of Lyme disease, Borrelia burgdorferi, localizes preferentially in the extracellular matrix during persistence. In chronically infected laboratory mice, there is a direct association between B. burgdorferi and the proteoglycan decorin, which…

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The Early Dissemination Defect Attributed to Disruption of Decorin-Binding Proteins Is Abolished in Chronic Murine Lyme Borreliosis

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doi: 10.1128/IAI.01359-12 Infect. Immun. May 2013 vol. 81 no. 5 1663-1673    Denise M. Imaia, D. Scott Samuelsb, Sunlian Fenga, Emir Hodzica, Kim Olsena and Stephen W. Bartholda Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis, Davis, California, USAa Division of Biological Sciences, The University of Montana, Missoula, Montana, USAb R. P. Morrison, Editor + Author…