Nitroxoline Drug Combinations Are More Active Than Lyme Antibiotic Combination and Can Eradicate Stationary Phase Borrelia burgdorferi
Abstract Lyme disease (LD), caused by Borrelia burgdorferi, is the most common vector-borne disease in USA and Europe. Despite the standard 2-4 weeks antibiotic treatment, approximately 10%-20% of patients will develop post-treatment LD syndrome, a condition that is poorly understood. One of the probable causes is thought to be the presence of B. burgdorferi persister forms that are not…