Whole-Genome Sequences of Thirteen Isolates of Borrelia burgdorferi

ByTeam
Campers stand at the edge of the water at sunset watching the stars come out, with the CanLyme logo floating in the foreground.

Journal of Bacteriology (JB) – American Society for Microbiology

Abstract

Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole-genome sequences of 13 additional B. burgdorferi isolates that span the range of natural variation. These sequences should allow improved understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies.

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