YebC regulates variable surface antigen VlsE expression and is required for host immune evasion in Borrelia burgdorferi
Oct. 2020 PLOS PATHOGENS Abstract Borrelia burgdorferi, the Lyme disease pathogen causes persistent infection by evading the host immune response. Differential expression of the surface-exposed lipoprotein VlsE that undergoes antigenic variation is a key immune evasion strategy employed by B. burgdorferi. Most studies focused on the mechanism of VlsE antigen variation, but little is known…