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Detection of Babesia odocoilei in Humans with Babesiosis Symptoms

ByCanLyme Team

Abstract Human babesiosis is a life-threatening infectious disease that causes societal and economic impact worldwide. Several species of Babesia cause babesiosis in terrestrial vertebrates, including humans. A one-day clinic was held in Ontario, Canada, to see if a red blood cell parasite, which is present in blacklegged ticks, Ixodes scapularis, is present in humans. Based on PCR testing…

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Detecting Borrelia Spirochetes: A Case Study With Validation Among Autopsy Specimens

ByCanLyme Team

The complex etiology of neurodegenerative disease has prompted studies on multiple mechanisms including genetic predisposition, brain biochemistry, immunological responses, and microbial insult. In particular, Lyme disease is often associated with neurocognitive impairment with variable manifestations between patients. We sought to develop methods to reliably detect Borrelia burgdorferi, the spirochete bacteria responsible for Lyme disease, in autopsy…

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Botanical Medicines Cryptolepis sanguinolenta, Artemisia annua, Scutellaria baicalensis, Polygonum cuspidatum, and Alchornea cordifolia Demonstrate Inhibitory Activity Against Babesia duncani

ByCanLyme Team

Front. Cell. Infect. Microbiol., 08 March 2021 | https://doi.org/10.3389/fcimb.2021.624745 “Human babesiosis is a CDC reportable disease in the United States and is recognized as an emerging health risk in multiple parts of the world. The current treatment for human babesiosis is suboptimal due to treatment failures and unwanted side effects. Although Babesia duncani was first described almost…

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ALS or ALS mimic by neuroborreliosis—A case report

ByCanLyme Team

[CanLyme Note: This report relates that their is reason to double check positive CSF PCR tests for Lyme disease. There is a very small risk of false positive results.  The bigger risk is false negative results as outlined in this presentation, “PCR testing of CSF is positive in only about one third of US patients with…

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Borrelia miyamotoi-An Emerging Human Tick-Borne Pathogen in Europe

ByCanLyme Team

[CanLyme Note: Canada has Borrelia miyamotoi coast to coast in ticks.] January 12, 2021 Abstract Borrelia miyamotoi is classified as a relapsing fever spirochete. Although B. miyamotoi is genetically and ecologically distinct from Borrelia burgdorferi sensu lato, both microorganisms are transmitted by the same Ixodes tick species. B. miyamotoi was detected in I. persulcatus ticks in 1994 in Japan. A phylogenetic analysis based on selected sequences of B….

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Borrelia burgdorferi-Induced Changes in the Class II Self-Immunopeptidome Displayed on HLA-DR Molecules Expressed by Dendritic Cells

ByCanLyme Team

September 2020 The MHC class II antigen processing and presentation pathway has evolved to derive short amino acid peptides from proteins that enter the endocytic pathway, load them onto MHC class II molecules and display them on the surface of antigen presenting cells for recognition by CD4+ T cells. Under normal circumstances, peptides bound to MHC…

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Phase 4 Block of the Right Bundle Branch Suggesting His-Purkinje System Involvement in Lyme Carditis

ByCanLyme Team

[CanLyme Note: As new research unfolds we are discovering that borrelia other than Borrelia burgdorferi (Bb) are pathogenic to humans.  Much research is required to garner a broader understanding of cardiovascular and other system involvement and presentation.  Testing currently is too focused on Bb and even with that it has many limitations and inaccuracies resulting in many…

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Will this latest Canadian research change the paradigm of testing and lab diagnostics for Lyme disease globally?

ByCanLyme Team

Abstract Serological diagnosis of Lyme disease suffers from considerable limitations. Yet, the technique cannot currently be replaced by direct detection methods, such as bacterial culture or molecular analysis, due to their inadequate sensitivity. The low bacterial burden in vasculature and lack of consensus around blood-based isolation of the causative pathogen, Borrelia burgdorferi, are central to this…

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Lyme Disease Patient Outcomes and Experiences; A Retrospective Cohort Study

ByCanLyme Team

Abstract Lyme disease is a vector-borne illness caused by Borrelia spp. bacterium spread by ticks to humans and other mammals. Despite being prevalent in many regions of the world, there remains considerable uncertainty surrounding many aspects of the disease, and consensus on the most appropriate and effective means of treating the illness remains to be achieved. Recommendations…

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Fatal Lyme carditis presenting as fluctuating high-grade atrioventricular block

ByCanLyme Team

RE: Lyme carditis and neuroborreliosis Edward J Cormode [MD, FRCP], Retired paediatrician, Canadian Medical Association The three cases presented in the “Practice “section of the May 25, 2020 CMAJ provide an informative discussion of the diagnosis and treatment of Lyme carditis and neuroborreliosis in a tertiary care centre. I am a retired Ontario pediatrician and coroner, having practiced for…

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Motivations and Experiences of Canadians Seeking Treatment for Lyme Disease Outside of the Conventional Canadian Health-Care System

ByCanLyme Team

Abstract   Objective: We aimed to describe the experiences of Canadians who seek diagnosis and treatment for Lyme disease outside of the conventional Canadian health-care system. Methods: Forty-five individuals who had sought treatment for Lyme disease outside of the conventional Canadian health-care system were recruited from Lyme support and advocacy groups across Canada to answer…

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A 4-year-old boy with ataxia and aphasia

ByCanLyme Team

[CanLyme Note: The rashes shown in this case are dismissed Canada-wide by doctors who are not taught about multiple rashes, and the worst of it is that if you are not in a “known endemic area” Lyme disease will be dismissed. In reality, Lyme disease occurs anywhere in Canada where our songbirds birds fly. If you…

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Chronic Lyme disease – does it exist?

ByCanLyme Team

“Her symptoms started quickly: neck pain, extreme fatigue and intermittent fever and chills. The woman had been healthy until then, and since she enjoyed gardening and landscaping at her rural Maryland home, she wondered if a tick bite might have given her Lyme disease although she had not noticed the telltale bull’s-eye skin lesion. Her…

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WSU researchers crack the Lyme disease code

ByCanLyme Team

The next time a tick feeds on you, Washington State University researchers hope to make sure persistent arthritis caused by Lyme disease doesn’t linger for a lifetime. Troy Bankhead, associate professor in WSU’s Veterinary Microbiology and Pathology department, and his team have spent more than a decade analyzing an immune evasive protein of Borrelia burgdorferi,…

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Lyme Disease: Diversity of Borrelia Species in California and Mexico Detected Using a Novel Immunoblot Assay

ByCanLyme Team

Abstract Background: With more than 300,000 new cases reported each year in the United States of America (USA), Lyme disease is a major public health concern. Borrelia burgdorferi sensu stricto (Bbss) is considered the primary agent of Lyme disease in North America. However, multiple genetically diverse Borrelia species encompassing the Borrelia burgdorferi sensu lato (Bbsl) complex and the Relapsing Fever Borrelia (RFB) group…