Ontario Lyme Alliance responds to article in the Canadian Medical Association Journal that missed the mark.
Re: Lyme disease: How reliable are serologic results? see also http://canlyme.com/?p=7245
Debra L. Fraleigh, Co-founder
Ontario Lyme Alliance
A thorough examination of the full text of the Fallon study (1), referenced by Gregson et al, demonstrates that for thirty-seven Lyme patients (all of whom met historical clinical AND laboratory criteria for LD) archived sera from fewer than half of these confirmed patients (37.8%- 48.6%) tested positive at each of all four laboratories using the CDC two- tiered algorithm for ELISA and IgG WB. The Fallon et al study also demonstrated a considerable lack of concordance among the labs; thus, patient sera may test positive at one lab but not another. This would suggest that the answer to the title question is: less reliable than a coin toss.