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Mar. 21, 2013 — Scientists have confirmed that the pathogen that causes Lyme Disease — unlike any other known organism — can exist without iron, a metal that all other life needs to make proteins and enzymes. Instead of iron, the bacteria substitute manganese to make an essential enzyme, thus eluding immune system defenses that protect the body by starving pathogens of iron.
Executive Summary In this third and final report of the Tick-Borne Disease Working Group, the committee applauds the progress that has been made during the past six years but recognizes the challenges that remain. The Working Group identified possible paths toward achieving its vision of “a nation free of tick-borne diseases where new infections are…
[ CanLyme note: Western Canadian ticks often come from migratory birds from California and other western states. Borrelia bissettii was found in the province of British Columbia well over a decade ago, yet there is still no human test that properly tests for it and many other Borrelia genotypes known to occur. Patients in Canada are…
Abstract: The diagnoses of Lyme disease based on clinical manifestations, serological findings and detection of infectious agents often contradict each other. We tested 52 blind-coded serum samples, including 20 pre-treatment and 12 post-treatment sera from clinically suspect Lyme disease patients, for the presence of residual Lyme disease infectious agents, using nested PCR amplification of a…
By Jamie Komarnicki, Calgary Herald May 20, 2014 7:28 PM With the number of confirmed Lyme disease cases rising in Alberta, the provincial government is going into the field for the first time to try to get a handle on whether the ticks that can transmit the bacteria to humans are surviving through the winter….
Summary Systemic dissemination of microbial pathogens permits microbes to spread from the initial site of infection to secondary target tissues and is responsible for most mortality due to bacterial infections. Dissemination is a critical stage of disease progression by the Lyme spirochaete, Borrelia burgdorferi. However, many mechanistic features of the process are not yet understood….
An in-depth review by three leading experts.
