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Lyme Disease symptoms vary from person to person. (lymes disease lyme's disease lime disease limes disease)
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Inactivation of a putative flagellar motor switch protein FliG1 prevents
Borrelia burgdorferi from swimming in highly viscous media and blocks
its infectivity
Chunhao Li, Hongbin Xu, Kai Zhang and Fang Ting Liang
Molecular Microbiology, Published online: February 18, 2010.
http://dx.doi.org/10.1111/j.1365-2958.2010.07078.x
Abstract
The flagellar motor switch complex protein FliG plays an essential role
in flagella biosynthesis and motility. In most motile bacteria, only one
fliG homologue is present in the genome. However, several spirochete
species have two putative fliG genes (referred to as fliG1 and fliG2)
and their roles in flagella assembly and motility remain unknown.
In this report, the Lyme disease spirochete Borrelia burgdorferi was
used as a genetic model to investigate the roles of these two fliG
homologues. It was found that fliG2 encodes a typical motor switch
complex protein that is required for the flagellation and motility of B.
burgdorferi. In contrast, the function of fliG1 is quite unique.
Disruption of fliG1 did not affect flagellation and the mutant was still
motile but failed to translate in highly viscous media. GFP-fusion and
motion tracking analyses revealed that FliG1 asymmetrically locates at
one end of cells and the loss of fliG1 somehow impacted one bundle of
flagella rotation. In addition, animal studies demonstrated that the
fliG1- mutant was quickly cleared after inoculation into the murine
host, which highlights the importance of the ability to swim in highly
viscous media in the infectivity of B. burgdorferi and probably other
pathogenic spirochetes.
http://dx.doi.org/10.1111/j.1365-2958.2010.07078.x
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