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Lyme Disease symptoms vary from person to person. (lymes disease lyme's disease lime disease limes disease)
The data and information presented in this web site are presented in good faith and believed to be accurate regarding Lyme disease (commonly misspelled lymes disease lyme's disease lime disease limes disease) and other related diseases. Any and all liability for the content or any omissions including any inaccuracies, errors, or misstatements in such data or information is expressly disclaimed. The web site is compiled for the sole purpose of informing community members of resources and information pertaining to Lyme Borreliosis Disease and its coinfections. Lyme disease symptoms may vary from person to person.
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Consult a qualified Lyme ( Borreliosis ) Disease literate doctor for medical advice if Lyme Disease is suspect to discuss your Lymes Disease Symptoms.
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Minerva Med. 2008 Oct;99(5):489-96.
Severity of Lyme disease with persistent symptoms. Insights from a
double-blind placebo-controlled clinical trial.
Cameron D.
Northern Westchester Hospital, Mount Kisco, NY, USA
cameron@lymeproject.com
Lyme disease is a global health concern and is the world's leading tick
borne infection caused by the spirochete, Borrelia burgdorferi, that has
been associated with numerous neurologic, rheumatologic and psychiatric
manifestations. The symptoms of Lyme disease have been characterized as
either severe or ''related to the aches and pains of daily living.''
A randomized double-blind, placebo-controlled clinical trial (RCT) was
conducted in a primary internal medicine practice in Westchester County, New
York, USA. A total of 84 adults with Lyme disease with persistent symptoms
(LDPS) were studied; 52 received amoxicillin and 34 received placebo. The
subjects received either placebo or amoxicillin 3 g per day orally for 3
months.
The SF-36 was used as the outcome measure of the patient's perceived
Quality of Life (QOL).
For subjects enrolling in this RCT, the average SF-36
physical component summary (PCS) of QOL (40+/-9, range 29-44) and mental
component summary (MCS) of QOL (39+/-14, range 23-46) were worse than the
general USA population and worse than individuals with diabetes, heart
disease, depression, osteoarthritis or rheumatoid arthritis.
The
improvements in the SF-36 measure of QOL for subjects randomized to
amoxicillin vs. placebo was significant (46% vs 18%, P=0.007).
It is important for clinicians to be aware that LDPS can be severe.
A significant
gain in the QOL for subjects randomized to amoxicillin in this RCT without
serious adverse events is consistent with the goal of improving patient's
QOL and consequently worthy of further study.
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